2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

• Catalog No.: 302309
• CAS Number: 89992-70-1
• M. F.: C9H18ClN2OP
• M. W.: 236.678781

SYNONYMS

• Title: 2-氰乙基N,N-二异丙基氯亚磷酰胺
• IUPAC name: 3-({[bis(propan-2-yl)amino](chloro)phosphanyl}oxy)propanenitrile
• IUPAC Traditional name: 3-{[chloro(diisopropylamino)phosphanyl]oxy}propanenitrile
• Synonyms: Chloro(diisopropylamino)-β-cyanoethoxyphosphine; 氯代(二异丙基氨基)-β-氰基乙氧基膦

DATABASE IDS

• MDL Number: MFCD00011544
• CAS Number: 89992-70-1
• Beilstein Number: 3588525
• PubChem SID: 24858245

PROPERTIES

• Compostion: Cl, 13.5-15.5%
• Linear Formula: [(CH3)2CH]2NP(Cl)OCH2CH2CN
• Density: 1.061 g/mL at 25 °C(lit.)
• Flash Point: 110 °C
• Flash Point: 230 °F
• GHS Signal Word: Danger
• GHS Hazard statements: H250-H314
• European Hazard Symbols: Corrosive (C)
• Personal Protective Equipment: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P222-P231-P280-P305 + P351 + P338-P310-P422
• RID/ADR: UN 2845 4.2/PG 1
• Risk Statements: 5-34
• Safety Statements: 26-36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 4.2
• UN Number: 2845
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Application
Phosphitylating reagent for 3′-hydroxyl groups for use in the synthesis of oligodeoxyribonucleotides.1,2,3,4
Used in a scalable, solution-phase oligonucleotide synthesis employing phosphoramidite chemistry and DMT-, iBu- and Bz-protected monomers. Intermediates were isolated by extraction without further purification.
Packaging
1, 5 g in glass bottle
250 mg in glass bottle

Description (简体中文)

Application
用于可扩展性液相寡核苷酸合成，该合成用于亚磷酰胺化学和 DMT-、iBu- 以及 Bz-保护单体。中间体可通过萃取分离，无需进一步纯化。
用于寡脱氧核糖核苷酸合成过程中 3′-羟基的磷化试剂。1,2,3,4
包装
1, 5 g in glass bottle
250 mg in glass bottle