L-Homoarginine hydrochloride

• Catalog No.: 157112
• CAS Number: 1483-01-8
• M. F.: C7H17ClN4O2
• M. W.: 224.68848
• Purity: 97%

SYNONYMS

• Title: L-高精氨酸 盐酸盐
• IUPAC name: (2S)-2-amino-6-carbamimidamidohexanoic acid hydrochloride
• IUPAC Traditional name: L-homoarginine hydrochloride
• Synonyms: (S)-2-Amino-6-guanidinohexanoic acid hydrochloride

DATABASE IDS

• MDL Number: MFCD00012622
• Beilstein Number: 4016621
• EC Number: 216-045-6
• CAS Number: 1483-01-8

PROPERTIES

• Linear Formula: H2NC(=NH)NH(CH2)4CH(NH2)CO2H · HCl
• Purity: 97%
• Melting Point: 213-215 °C(lit.)
• Optical Rotation: [α]26/D +19°, c = 1 in 1 M HCl
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Application
The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.
Biochem/physiol Actions
Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

Description (简体中文)

Application
The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.
Biochem/physiol Actions
Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.