3-Maleimidobenzoic acid N-hydroxysuccinimide ester

• Catalog No.: 286532
• CAS Number: 58626-38-3
• M. F.: C15H10N2O6
• M. W.: 314.2497
• Purity: 97%

SYNONYMS

• Title: 3-马来酰亚胺基苯甲酸琥珀酰亚胺酯
• IUPAC name: 2,5-dioxopyrrolidin-1-yl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
• IUPAC Traditional name: 2,5-dioxopyrrolidin-1-yl 3-(2,5-dioxopyrrol-1-yl)benzoate
• Synonyms: MBS

DATABASE IDS

• CAS Number: 58626-38-3
• Beilstein Number: 1505254
• MDL Number: MFCD00005514

PROPERTIES

• Empirical Formula (Hill Notation): C15H10N2O6
• Purity: 97%
• Melting Point: 175-177 °C(lit.)
• European Hazard Symbols: Irritant (Xi)
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• German water hazard class: -

DETAILS

Description (English)

Application
Heterobifunctional crosslinking reagent reactive toward primary amine and sulfhydryl. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.0, followed by coupling to compounds containing sulfhydryl by thioether at same pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
Other Notes
The aryl maleimide is less stable than alkyl maleimide linkers.

Description (简体中文)

Application
对伯胺和巯基具有反应性的双异官能化交联剂。通常，初始反应在 pH 为 7.0 时，通过酰胺键偶联至含伯胺的分子，然后在相同 pH 通过硫醚偶联至含巯基的化合物。用于制备酶免疫交联剂和半抗原载体分子偶联物。
Other Notes
芳基马来酰亚胺比烷基马来酰亚胺连接基更不稳定。