trans-Dehydroandrosterone

• Catalog No.: 125784
• CAS Number: 53-43-0
• M. F.: C19H28O2
• M. W.: 288.42442
• Purity: 97%

SYNONYMS

• Title: 反式-脱氢雄甾酮
• IUPAC name: (1S,2R,5S,10R,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-en-14-one
• IUPAC Traditional name: dehydroepiandrosterone
• Synonyms: 3β-羟基-5-雄烯-17-酮; 雄素-5-烯-3β-醇-17-酮; 3β-Hydroxy-5-androsten-17-one; 普拉睾酮; DHEA; 去氢表雄酮; 脱氢异雄酮; 5-Androsten-3β-ol-17-one; Dehydroepiandrosterone; Dehydroisoandrosterone; Prasterone

DATABASE IDS

• Beilstein Number: 2058110
• CAS Number: 53-43-0
• EC Number: 200-175-5
• MDL Number: MFCD00003613

PROPERTIES

• Empirical Formula (Hill Notation): C19H28O2
• Purity: 97%
• Melting Point: 149-151 °C(lit.)
• Optical Rotation: [α]25/D +13.0°, c = 1 in ethanol
• Drug Control: regulated under CDSA - not available from Sigma-Aldrich Canada
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: BV8396000
• Safety Statements: 26-36
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.1

Description (简体中文)

Biochem/physiol Actions
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.1