(3S-cis)-(+)-Tetrahydro-3-isopropyl-7a-phenylpyrrolo[2,1-b]oxazol-5(6H)-one

• Catalog No.: 335398
• CAS Number: 88670-16-0
• M. F.: C15H19NO2
• M. W.: 245.31686
• Purity: 98%

SYNONYMS

• Title: (3S-顺)-(+)-四氢-3-异丙基-7a-苯基吡咯并[2,1-b]噁唑-5(6H)-酮
• IUPAC name: (3S,7aS)-7a-phenyl-3-(propan-2-yl)-hexahydropyrrolo[2,1-b][1,3]oxazol-5-one
• IUPAC Traditional name: (3S,7aS)-3-isopropyl-7a-phenyl-tetrahydropyrrolo[2,1-b][1,3]oxazol-5-one

DATABASE IDS

• CAS Number: 88670-16-0
• MDL Number: MFCD00075054

PROPERTIES

• Empirical Formula (Hill Notation): C15H19NO2
• Purity: 98%
• Melting Point: 56-58 °C(lit.)
• Optical Rotation: [α]25/D +70°, c = 1.5 in chloroform
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• German water hazard class: 3

DETAILS

Description (English)

Application
Chiral bicyclic lactams such as this are useful templates for the asymmetric synthesis of a variety of natural and unnatural products.1 High levels of asymmetric induction have been obtained in cycloadditions,2,3 alkylations,4,5,6 conjugate additions,7,8 annulations,9 and dihydroxylations.10

Description (简体中文)

Application
像这样的手性双环内酰胺类化合物是不对称合成许多天然和非天然产物的有用模板。1已在以下反应中实现了高水平的不对称诱导：环加成、2,3烷基化、4,5,6共轭加成、7,8成环9以及双羟基化。10