Flurbiprofen

• Catalog No.: 447994
• CAS Number: 5104-49-4
• M. F.: C15H13FO2
• M. W.: 244.2609232
• Purity: 97%

SYNONYMS

• Title: 氟比洛芬
• IUPAC name: 2-(3-fluoro-4-phenylphenyl)propanoic acid
• IUPAC Traditional name: flurbiprofen
• Synonyms: L-790,330; (±)-2-Fluoro-α-methyl-4-biphenylacetic acid; (±)-2-氟-α-甲基-4-联苯基乙酸

DATABASE IDS

• MDL Number: MFCD00079303
• EC Number: 225-827-6
• CAS Number: 5104-49-4

PROPERTIES

• Linear Formula: C6H5C6H3(F)CH(CH3)CO2H
• Purity: 97%
• Melting Point: 110-112 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• RTECS: DU8341000
• Safety Statements: 36/37/39-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Description (简体中文)

Biochem/physiol Actions
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.