3-Isobutyl-1-methylxanthine

• Catalog No.: 858455
• CAS Number: 28822-58-4
• M. F.: C10H14N4O2
• M. W.: 222.24376
• Purity: 99%

SYNONYMS

• Title: 3-异丁基-1-甲基黄嘌呤
• IUPAC name: 1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: 3 isobutyl 1 methylxanthine
• Synonyms: 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione; 1-Methyl-3-isobutylxanthine; 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮; 1-甲基-3-异丁基黄嘌呤; 3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮; 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione; IBMX

DATABASE IDS

• Beilstein Number: 247859
• MDL Number: MFCD00005584
• CAS Number: 28822-58-4
• EC Number: 249-259-3

PROPERTIES

• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Risk Statements: 22
• RTECS: ZD8500000
• German water hazard class: 3
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Empirical Formula (Hill Notation): C10H14N4O2
• Purity: 99%
• Melting Point: 200-201 °C(lit.)

DETAILS

Description (English)

Application
Potent inhibitor of cyclic nucleotide phosphodiesterase.2,3
Packaging
1 g in glass bottle
100 mg in glass bottle
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1

Description (简体中文)

Application
环核苷酸磷酸二酯酶蛋白抑制剂2,3
包装
1 g in glass bottle
100 mg in glass bottle
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1