8-Methoxypsoralen

• Catalog No.: 232726
• CAS Number: 298-81-7
• M. F.: C12H8O4
• M. W.: 216.18952
• Purity: 99%

SYNONYMS

• Title: 8-甲氧基补骨脂素
• IUPAC name: 9-methoxy-7H-furo[3,2-g]chromen-7-one
• IUPAC Traditional name: methoxsalen
• Synonyms: 8-MOP; 花椒毒内酯; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; 花椒毒素; Ammoidin; Methoxsalen; Xanthotoxin; 9-甲氧基呋喃并[3,2-g][1]苯并吡喃-7-酮; 甲氧沙林

DATABASE IDS

• EC Number: 206-066-9
• CAS Number: 298-81-7
• MDL Number: MFCD00005009
• Beilstein Number: 196453

PROPERTIES

• Empirical Formula (Hill Notation): C12H8O4
• Purity: 99%
• Melting Point: 148-150 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P342 + P311
• Risk Statements: 22-43
• RTECS: LV1400000
• Safety Statements: 36/37
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].

Description (简体中文)

Biochem/physiol Actions
8-甲氧基补骨脂素 (8-MOP) 加 A 波紫外线 (UVA) 辐射可诱导单加合物形成和 DNA 链间交联，因此可用于研究 DNA 修复和重组机制。培养的正常人黑素细胞经 8-甲氧基补骨脂素处理和 A 波紫外线 (UVA) 照射后形成 8-甲氧基补骨脂素-磷脂光加成产物，经二酰甘油取代后可在无细胞体系中激活蛋白激酶 C。8-MOP 是纯化重组细胞色素 P450 的灭活剂。它还可以通过抑制 [Ca2+] 的升高，而抑制从 P 物质激活的大鼠腹膜肥大细胞的 P 物质诱导型组胺释放。