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(3S-cis)-(+)-Tetrahydro-3,7a-diphenylpyrrolo[2,1-b]oxazol-5(6H)-one_Molecular_structure_CAS_161970-71-4)
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(3S-cis)-(+)-Tetrahydro-3,7a-diphenylpyrrolo[2,1-b]oxazol-5(6H)-one

Catalog No. 458538 Name Sigma Aldrich
CAS Number 161970-71-4 Website http://www.sigmaaldrich.com
M. F. C18H17NO2 Telephone 1-800-521-8956
M. W. 279.33308 Fax
Purity 98% Email
Storage Chembase ID: 137294

SYNONYMS

Title
(3S-顺)-(+)-四氢-3,7a-二苯基吡咯并[2,1-b]噁唑-5(6H)-酮
IUPAC name
(3S,7aS)-3,7a-diphenyl-hexahydropyrrolo[2,1-b][1,3]oxazol-5-one
IUPAC Traditional name
(3S,7aS)-3,7a-diphenyl-tetrahydropyrrolo[2,1-b][1,3]oxazol-5-one

DATABASE IDS

MDL Number MFCD00274329
PubChem SID 24869475
CAS Number 161970-71-4

PROPERTIES

Empirical Formula (Hill Notation) C18H17NO2
Purity 98%
Melting Point 82-85 °C(lit.)
Optical Rotation [α]20/D +113°, c = 1 in chloroform
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
Safety Statements 26-36
German water hazard class 3

DETAILS

Description (English)
Application
Chiral bicyclic lactams such as this are useful templates for the asymmetric synthesis of a variety of natural and unnatural products.1 High levels of asymmetric induction have been obtained in cycloadditions,2,3 alkylations,4,5,6 conjugate additions,7,8 annulations,9 and dihydroxylations.10
Description (简体中文)
Application
像这样的手性双环内酰胺类化合物是不对称合成许多天然和非天然产物的有用模板。1已在以下反应中实现了高水平的不对称诱导:环加成、2,3烷基化、4,5,6共轭加成、7,8成环9以及双羟基化。10

REFERENCES