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(R)-(+)-3-Chlorostyrene oxide_Molecular_structure_CAS_62600-71-9)
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(R)-(+)-3-Chlorostyrene oxide

Catalog No. 440868 Name Sigma Aldrich
CAS Number 62600-71-9 Website http://www.sigmaaldrich.com
M. F. C8H7ClO Telephone 1-800-521-8956
M. W. 154.59358 Fax
Purity 98% Email
Storage Chembase ID: 77520

SYNONYMS

Title
(R)-(+)-(3-氯苯基)环氧乙烷
IUPAC name
(2R)-2-(3-chlorophenyl)oxirane
IUPAC Traditional name
(2R)-2-(3-chlorophenyl)oxirane
Synonyms
(R)-(+)-(3-Chlorophenyl)oxirane

DATABASE IDS

CAS Number 62600-71-9
MDL Number MFCD00673317

PROPERTIES

Empirical Formula (Hill Notation) C8H7ClO
Purity 98%
Boiling Point 67-68 °C/1 mmHg(lit.)
Density 1.214 g/mL at 25 °C(lit.)
Flash Point 97 °C
Flash Point 206.6 °F
Optical Rotation [α]20/D +21°, neat
Refractive Index n20/D 1.551(lit.)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H317-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
GHS Precautionary statements P261-P280-P305 + P351 + P338
Risk Statements 36/37/38-43
Safety Statements 26-36/37
German water hazard class 3

DETAILS

Description (English)
Application
Key chiral synthon for the preparation of the potent antidiabetic and antiobesity agent CL-316,243, a benzodioxole-containing phenethanolamine.8 Ring opening of this chiral epoxide with amines produces amino alcohols which have been used as β-adrenergic agonists.9
Reactant involved in:
• Diastereoselective Wadsworth-Emmons cyclopropanation for synthesis of quaternaty cyclopropyl esters1
• Synthesis of phenylethanolamine derivatives as β3-adrenergic receptor agonists2,3
• Stereoselective ring-opening for synthesis of β-aryloxy-substituted alcohols and amines4
• Synthesis of Biphenyl benzoic acid derivatives as β3-adrenergic receptor agonists5,6
• Synthesis of (S)-2-, 3-, and 4-chlorostyrene oxides with epoxide hydrolase7
Description (简体中文)
Application
重要的手性合成子,用于制备强效治糖尿病药和减肥药 CL-316,243,CL-316,243 是一种含苯并二茂的苯乙醇胺。8该手性环氧化物与胺的开环反应可产生氨基醇类化合物,用作 β-肾上腺素激动剂。9
Reactant involved in:
• Diastereoselective Wadsworth-Emmons cyclopropanation for synthesis of quaternaty cyclopropyl esters1
• Synthesis of phenylethanolamine derivatives as β3-adrenergic receptor agonists2,3
• Stereoselective ring-opening for synthesis of β-aryloxy-substituted alcohols and amines4
• Synthesis of Biphenyl benzoic acid derivatives as β3-adrenergic receptor agonists5,6
• Synthesis of (S)-2-, 3-, and 4-chlorostyrene oxides with epoxide hydrolase7

REFERENCES