(R)-(+)-3-Chlorostyrene oxide

• Catalog No.: 440868
• CAS Number: 62600-71-9
• M. F.: C8H7ClO
• M. W.: 154.59358
• Purity: 98%

SYNONYMS

• Title: (R)-(+)-(3-氯苯基)环氧乙烷
• IUPAC name: (2R)-2-(3-chlorophenyl)oxirane
• IUPAC Traditional name: (2R)-2-(3-chlorophenyl)oxirane
• Synonyms: (R)-(+)-(3-Chlorophenyl)oxirane

DATABASE IDS

• CAS Number: 62600-71-9
• MDL Number: MFCD00673317

PROPERTIES

• Density: 1.214 g/mL at 25 °C(lit.)
• Flash Point: 97 °C
• Flash Point: 206.6 °F
• Optical Rotation: [α]20/D +21°, neat
• Refractive Index: n20/D 1.551(lit.)
• Boiling Point: 67-68 °C/1 mmHg(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H317-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 36/37/38-43
• Safety Statements: 26-36/37
• German water hazard class: 3
• Empirical Formula (Hill Notation): C8H7ClO
• Purity: 98%

DETAILS

Description (English)

Application
Key chiral synthon for the preparation of the potent antidiabetic and antiobesity agent CL-316,243, a benzodioxole-containing phenethanolamine.8 Ring opening of this chiral epoxide with amines produces amino alcohols which have been used as β-adrenergic agonists.9
Reactant involved in:
• Diastereoselective Wadsworth-Emmons cyclopropanation for synthesis of quaternaty cyclopropyl esters1
• Synthesis of phenylethanolamine derivatives as β3-adrenergic receptor agonists2,3
• Stereoselective ring-opening for synthesis of β-aryloxy-substituted alcohols and amines4
• Synthesis of Biphenyl benzoic acid derivatives as β3-adrenergic receptor agonists5,6
• Synthesis of (S)-2-, 3-, and 4-chlorostyrene oxides with epoxide hydrolase7

Description (简体中文)

Application
重要的手性合成子，用于制备强效治糖尿病药和减肥药 CL-316,243，CL-316,243 是一种含苯并二茂的苯乙醇胺。8该手性环氧化物与胺的开环反应可产生氨基醇类化合物，用作 β-肾上腺素激动剂。9
Reactant involved in:
• Diastereoselective Wadsworth-Emmons cyclopropanation for synthesis of quaternaty cyclopropyl esters1
• Synthesis of phenylethanolamine derivatives as β3-adrenergic receptor agonists2,3
• Stereoselective ring-opening for synthesis of β-aryloxy-substituted alcohols and amines4
• Synthesis of Biphenyl benzoic acid derivatives as β3-adrenergic receptor agonists5,6
• Synthesis of (S)-2-, 3-, and 4-chlorostyrene oxides with epoxide hydrolase7