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(Trimethylsilyl)diazomethane solution_Molecular_structure_CAS_18107-18-1)
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(Trimethylsilyl)diazomethane solution

Catalog No. 527254 Name Sigma Aldrich
CAS Number 18107-18-1 Website http://www.sigmaaldrich.com
M. F. C4H10N2Si Telephone 1-800-521-8956
M. W. 114.2211 Fax
Purity Email
Storage Chembase ID: 130014

SYNONYMS

Title
三甲基硅烷化重氮甲烷 溶液
IUPAC name
(diazomethyl)trimethylsilane
IUPAC Traditional name
trimethylsilyldiazomethane
Synonyms
(三甲硅烷)重氮甲烷
(Diazomethyl)trimethylsilane

DATABASE IDS

Beilstein Number 1902903
MDL Number MFCD00053946
PubChem SID 24874613
CAS Number 18107-18-1

PROPERTIES

Concentration 2.0 M in diethyl ether
Linear Formula (CH3)3SiCHN2
Density 0.773 g/mL at 25 °C
Flash Point -35 °C
Flash Point -31 °F
GHS Pictograms GHS02
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H225-H302-H330-H336-H350-H370
European Hazard Symbols Flammable Flammable (F)
European Hazard Symbols Highly toxic Highly toxic (T+)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS Precautionary statements P201-P210-P260-P284-P310
RID/ADR UN 1992 3/PG 1
Risk Statements 45-11-19-22-26-39/26-66-67
Safety Statements 53-16-28-36/37-45
Storage Temperature 2-8°C
Supplemental Hazard Statements May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.
Hazard Class 3
UN Number 1992
Packing Group 1
German water hazard class 3

DETAILS

Description (English)
Packaging
5, 25, 100 mL in Sure/Seal™
Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9
Description (简体中文)
包装
5, 25, 100 mL in Sure/Seal™
Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9

REFERENCES