(Trimethylsilyl)diazomethane solution

• Catalog No.: 527254
• CAS Number: 18107-18-1
• M. F.: C4H10N2Si
• M. W.: 114.2211

SYNONYMS

• Title: 三甲基硅烷化重氮甲烷 溶液
• IUPAC name: (diazomethyl)trimethylsilane
• IUPAC Traditional name: trimethylsilyldiazomethane
• Synonyms: (三甲硅烷)重氮甲烷; (Diazomethyl)trimethylsilane

DATABASE IDS

• Beilstein Number: 1902903
• MDL Number: MFCD00053946
• PubChem SID: 24874613
• CAS Number: 18107-18-1

PROPERTIES

• Concentration: 2.0 M in diethyl ether
• Linear Formula: (CH3)3SiCHN2
• Density: 0.773 g/mL at 25 °C
• Flash Point: -35 °C
• Flash Point: -31 °F
• GHS Signal Word: Danger
• GHS Hazard statements: H225-H302-H330-H336-H350-H370
• European Hazard Symbols: Flammable (F)
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P201-P210-P260-P284-P310
• RID/ADR: UN 1992 3/PG 1
• Risk Statements: 45-11-19-22-26-39/26-66-67
• Safety Statements: 53-16-28-36/37-45
• Storage Temperature: 2-8°C
• Supplemental Hazard Statements: May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.
• Hazard Class: 3
• UN Number: 1992
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Packaging
5, 25, 100 mL in Sure/Seal™
Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9

Description (简体中文)

包装
5, 25, 100 mL in Sure/Seal™
Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9