L-Glutathione reduced

• Catalog No.: G4705
• CAS Number: 70-18-8
• M. F.: C10H17N3O6S
• M. W.: 307.32348
• Purity: 98%

SYNONYMS

• Title: L-还原型谷胱甘肽
• IUPAC name: (2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid
• IUPAC Traditional name: glutathione
• Synonyms: GSH; 5-L-谷氨酰-L-半胱氨酰甘氨酸; γ-L-Glutamyl-L-cysteinyl-glycine

DATABASE IDS

• MDL Number: MFCD00065939
• EC Number: 200-725-4
• CAS Number: 70-18-8
• Beilstein Number: 1729812

PROPERTIES

• Linear Formula: H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
• Purity: 98%
• Melting Point: 192-195 °C (dec.)(lit.)
• Optical Rotation: [α]25/D -17.0°, c = 2 in H2O
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: MC0556000
• German water hazard class: 2

DETAILS

Description (English)

Amino Acid Sequence
γ-Glu-Cys-Gly
Application
Biological antioxidant1 that has been used with antitumor agents to enhance activity2 or to reduce side effects.3
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Biochem/physiol Actions
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Description (简体中文)

Amino Acid Sequence
γ-Glu-Cys-Gly
Application
可用 5-10mM 浓度的产品从谷胱甘肽琼脂糖中洗提谷胱甘肽 S-转移酶 (GST)。
生物抗氧化剂1，已与抗肿瘤剂共同用于提高活性2或者降低副作用。3
Biochem/physiol Actions
在细胞代谢和突发性呼吸期间形成的活性氧还原中发挥重要作用的内源性抗氧化剂。谷胱甘肽-S-转移酶催化谷胱甘肽硫醚与异生物、白三烯和其他具有亲电中心的分子的形成。谷胱甘肽还与蛋白质中半胱氨酸残基形成二硫键。通过这些机制，它可具有降低抗癌剂效用的奇异效果。