Caffeine

• Catalog No.: 56396
• CAS Number: 58-08-2
• M. F.: C8H10N4O2
• M. W.: 194.1906

SYNONYMS

• Title: 咖啡因
• IUPAC name: 1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: caffeine
• Synonyms: 1,3,7-Trimethylxanthine; 1,3,7-三甲基黄嘌呤

DATABASE IDS

• CAS Number: 58-08-2
• EC Number: 200-362-1
• MDL Number: MFCD00005758
• Beilstein Number: 17705

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• RTECS: EV6475000
• German water hazard class: 1
• Empirical Formula (Hill Notation): C8H10N4O2
• Grade: certified reference material
• Grade: TraceCERT®
• Melting Point: 234-236.5 °C(lit.)

DETAILS

Description (English)

General description
Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com.
Biochem/physiol Actions
A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.
Legal Information
TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC

Description (简体中文)

General description
Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com.
Biochem/physiol Actions
一种据信是通过腺苷受体和单胺类神经递质发挥作用的中枢神经系统兴奋剂。它为腺苷受体拮抗剂和腺苷3′，5′-环单磷酸 (cAMP) 磷酸二酯酶抑制剂。因此，在用咖啡因处理后，细胞内 cAMP 的水平将升高。据报道，它会影响细胞的钙水平，从而使细胞内的钙离子外流。它会使多种化学物质(例如蛋白酶抑制剂)的细胞周期效应无效，从而防止细胞凋亡;同时，还发现它可以抑制细胞的 DNA 修复机制。
法律信息
TraceCERT 注册商标 Sigma-Aldrich Co. LLC