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Caffeine

Catalog No. 56396 Name Sigma Aldrich
CAS Number 58-08-2 Website http://www.sigmaaldrich.com
M. F. C8H10N4O2 Telephone 1-800-521-8956
M. W. 194.1906 Fax
Purity Email
Storage Chembase ID: 86

SYNONYMS

Title
咖啡因
IUPAC name
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
IUPAC Traditional name
caffeine
Synonyms
1,3,7-Trimethylxanthine
1,3,7-三甲基黄嘌呤

DATABASE IDS

CAS Number 58-08-2
EC Number 200-362-1
MDL Number MFCD00005758
Beilstein Number 17705

PROPERTIES

GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Risk Statements 22
RTECS EV6475000
German water hazard class 1
Empirical Formula (Hill Notation) C8H10N4O2
Grade certified reference material
Grade TraceCERT®
Melting Point 234-236.5 °C(lit.)

DETAILS

Description (English)
General description
Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com.
Biochem/physiol Actions
A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.
Legal Information
TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC
Description (简体中文)
General description
Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com.
Biochem/physiol Actions
一种据信是通过腺苷受体和单胺类神经递质发挥作用的中枢神经系统兴奋剂。它为腺苷受体拮抗剂和腺苷3′,5′-环单磷酸 (cAMP) 磷酸二酯酶抑制剂。因此,在用咖啡因处理后,细胞内 cAMP 的水平将升高。据报道,它会影响细胞的钙水平,从而使细胞内的钙离子外流。它会使多种化学物质(例如蛋白酶抑制剂)的细胞周期效应无效,从而防止细胞凋亡;同时,还发现它可以抑制细胞的 DNA 修复机制。
法律信息
TraceCERT 注册商标 Sigma-Aldrich Co. LLC

REFERENCES