S-(4-Nitrobenzyl)-6-thioinosine

• Catalog No.: 861499
• CAS Number: 38048-32-7
• M. F.: C17H17N5O6S
• M. W.: 419.41178
• Purity: 98%

SYNONYMS

• Title: S-(4-硝基苄基)-6-硫肌苷
• IUPAC name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}-9H-purin-9-yl)oxolane-3,4-diol
• IUPAC Traditional name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}purin-9-yl)oxolane-3,4-diol
• Synonyms: NBTI; 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine; NBMPR; 6-[(4-硝基苄基)硫代]-9-β-D-呋喃核糖基嘌呤

DATABASE IDS

• EC Number: 253-753-4
• MDL Number: MFCD00005745
• CAS Number: 38048-32-7

PROPERTIES

• Empirical Formula (Hill Notation): C17H17N5O6S
• Purity: 98%
• Melting Point: 187-190 °C(lit.)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: UO9025000
• German water hazard class: 3

DETAILS

Description (English)

Application
A very potent inhibitor of nucleoside transport. NBMPR, in cultures, binds tightly but reversibly to tumor membrane sites associated with the nucleoside transport mechanism and is, therefore, a useful tool for cancer research.
Biochem/physiol Actions
Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system1 and vascular smooth muscle.2

Description (简体中文)

Application
极强的核苷转运抑制剂。在培养中，NBMPR 可牢固但可逆地结合到与核苷转运机制相关的肿瘤细胞膜位点上，因此是一种可用于癌症研究的有用工具。
Biochem/physiol Actions
Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system1 and vascular smooth muscle.2