Spermine

• Catalog No.: S3836
• CAS Number: 71-44-3
• M. F.: C10H26N4
• M. W.: 202.34024
• Purity: 98%

SYNONYMS

• Title: 精胺
• IUPAC name: (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine
• IUPAC Traditional name: spermine
• Synonyms: 精素; N,N′-Bis(3-aminopropyl)-1,4-diaminobutane; Gerontine; N,N′-双(3-氨基丙基)-1,4-丁二胺; 肌胺; 肝胺; Musculamine; Neuridine

DATABASE IDS

• CAS Number: 71-44-3
• EC Number: 200-754-2
• MDL Number: MFCD00008215
• Beilstein Number: 1750791

PROPERTIES

• Linear Formula: NH2(CH2)3NH(CH2)4NH(CH2)3NH2
• Purity: 98%
• Boiling Point: 150 °C/5 mmHg(lit.)
• Flash Point: 110 °C
• Flash Point: 230 °F
• Melting Point: 28-30(lit.)
• European Hazard Symbols: Corrosive (C)
• RID/ADR: UN 3259 8/PG 2
• Risk Statements: 34
• RTECS: EJ7175000
• Safety Statements: 26-36/37/39-45
• Hazard Class: 8
• UN Number: 3259
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Packaging
1 g in glass bottle
Biochem/physiol Actions
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Description (简体中文)

包装
1 g in glass bottle
Biochem/physiol Actions
多胺位点混合型 NMDA 谷氨酸受体激动剂/拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。