Tetrahydrofolic acid

• Catalog No.: DB00116
• CAS Number: 135-16-0
• M. F.: C19H23N7O6
• M. W.: 445.42922

SYNONYMS

• IUPAC name: (2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
• IUPAC Traditional name: @tetrahydrofolic acid
• Synonyms: 5,6,7,8-tetrahydrofolate; tetrahydropteroylglutamate; tetra-H-folate; tetrahydrofolate; th-folate; N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)glutamic acid; tetrahydropteroyl mono-L-glutamate; tetrahydrafolate; H4PteGlu; THF; folate-H4; FH4; 5,6,7,8-tetrahydrofolic acid; (6S)-tetrahydrofolate

DATABASE IDS

• PubChem CID: 91443
• CAS Number: 135-16-0
• PubChem SID: 46504756

PROPERTIES

• Hydrophobicity(logP): -2.7

DETAILS

Description (English)

• Drug Groups: approved; nutraceutical
• Description: Tetrahydrofolic acid is a folic acid derivative. It is produced from dihydrofolic acid by dihydrofolate reductase.; It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes.
• Indication: For nutritional supplementation, also for treating dietary shortage or imbalance.
• Pharmacology: Tetrahydrofolate is the main active metabolite of dietary folate. It is vital as a coenzyme in reactions involving transfers of single carbon groups. Tetrahydrofolate has a role in nucleic and amino acid synthesis. As nucleic and amino acid synthesis is affected by a deficiency of tetrahydrofolate, actively dividing and growing cells tend to be the first affected. Tetrahydrofolate is used to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
• Affected Organisms: Humans and other mammals
• External Links: Wikipedia