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Tetrahydrofolic acid

Catalog No. DB00116 Name DrugBank
CAS Number 135-16-0 Website http://www.ualberta.ca/
M. F. C19H23N7O6 Telephone (780) 492-3111
M. W. 445.42922 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 3

SYNONYMS

IUPAC name
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
IUPAC Traditional name
@tetrahydrofolic acid
Synonyms
tetrahydropteroylglutamate
tetrahydropteroyl mono-L-glutamate
tetrahydrafolate
tetra-H-folate
tetrahydrofolate
N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)glutamic acid
H4PteGlu
th-folate
THF
folate-H4
FH4
5,6,7,8-tetrahydrofolic acid
5,6,7,8-tetrahydrofolate
(6S)-tetrahydrofolate

DATABASE IDS

CAS Number 135-16-0
PubChem CID 91443
PubChem SID 46504756

PROPERTIES

Hydrophobicity(logP) -2.7

DETAILS

Description (English)
Item Information
Drug Groups approved; nutraceutical
Description Tetrahydrofolic acid is a folic acid derivative. It is produced from dihydrofolic acid by dihydrofolate reductase.
It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes.
Indication For nutritional supplementation, also for treating dietary shortage or imbalance.
Pharmacology Tetrahydrofolate is the main active metabolite of dietary folate. It is vital as a coenzyme in reactions involving transfers of single carbon groups. Tetrahydrofolate has a role in nucleic and amino acid synthesis. As nucleic and amino acid synthesis is affected by a deficiency of tetrahydrofolate, actively dividing and growing cells tend to be the first affected. Tetrahydrofolate is used to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
Affected Organisms
Humans and other mammals
External Links
Wikipedia

REFERENCES