N-Acetyl-D-glucosamine

• Catalog No.: DB00141
• CAS Number: 7512-17-6
• M. F.: C8H15NO6
• M. W.: 221.2078

SYNONYMS

• IUPAC name: N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• IUPAC Traditional name: N-acetyl-D-glucosamine
• Brand Name: GS-500; Natures Blend Glucosamine; Maxi GS; Aflexa
• Synonyms: NAG; Glucosamine Complex; 2-Acetamido-2-deoxy-D-glucose; GlcNAc; N-Acetylchitosamine

DATABASE IDS

• CAS Number: 7512-17-6

PROPERTIES

• Hydrophobicity(logP): -2.1

DETAILS

Description (English)

• Drug Groups: approved; nutraceutical
• Description: The N-acetyl derivative of glucosamine. [PubChem]
• Indication: For the treatment and prevention of osteoarthritis, by itself or in combination with chondroitin sulfate.
• Toxicity: Mouse, intravenous LD₅₀ is 4170 mg/kg. Side effects that have been reported are mainly mild gastrointestinal complaints such as heartburn, epigastric distress and diarrhea. No allergic reactions have been reported including sulfa-allergic reactions to glucosamine sulfate.
• Affected Organisms: Humans and other mammals
• Biotransformation: A significant fraction of ingested glucosamine is catabolized by first-pass metabolism in the liver.
• Absorption: Approximately 90% of orally administered glucosamine (salt form) gets absorbed from the small intestine.
• External Links: PDRhealth