| Item |
Information |
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Drug Groups
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approved; nutraceutical |
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Description
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Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem] |
| Indication |
For the treatment of ariboflavinosis (vitamin B2 deficiency). |
| Pharmacology |
Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts. |
| Affected Organisms |
| • |
Humans and other mammals |
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| Biotransformation |
Hepatic. |
| Absorption |
Vitamin B2 is readily absorbed from the upper gastrointestinal tract. |
| Half Life |
66-84 minutes |
| Protein Binding |
60% |
| References |
| • |
Zempleni J, Galloway JR, McCormick DB: Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr. 1996 Jan;63(1):54-66.
[Pubmed]
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