Cidofovir

• Catalog No.: DB00369
• CAS Number: 113852-37-2
• M. F.: C8H14N3O6P
• M. W.: 279.187021

SYNONYMS

• IUPAC name: ({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
• IUPAC Traditional name: cidofovir
• Brand Name: HPMPC; Vistide
• Synonyms: Cidofovir Anhydrous; CDV

DATABASE IDS

• PubChem SID: 46506054
• CAS Number: 113852-37-2
• PubChem CID: 60613

PROPERTIES

• Hydrophobicity(logP): -3.9
• Solubility: =170 mg/mL at pH 6-8

DETAILS

Description (English)

• Drug Groups: approved
• Description: Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. [Wikipedia]
• Indication: For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
• Pharmacology: Cidofovir is a new anti-viral drug. It is classified as a nucleotide analogue and is active against herpes cytomegalovirus (CMV) retinitis infection. Most adults are infected with CMV. Cidofovir suppresses cytomegalovirus (CMV) replication by selective inhibition of viral DNA synthesis.
• Toxicity: Kidney damage, fall in the number of white blood cells, decreased platelets
• Affected Organisms: Human Immunodeficiency Virus
• Absorption: 100%
• Half Life: 2.4 to 3.2 hours
• Protein Binding: 6%
• Distribution: * 537 ± 126 mL/kg [VISTIDE ADMINISTERED WITHOUT PROBENECID]; * 410 ± 102 mL/kg [VISTIDE ADMINISTERED WITH PROBENECID]
• Clearance: * 179 +/- 23.1 mL/min/1.73 m2 [WITHOUT PROBENECID]; * 148 +/- 38.8 mL/min/1.73 m2 [WITH PROBENECID]
• External Links: Wikipedia; RxList; Drugs.com