Fusidic Acid

• Catalog No.: DB02703
• CAS Number: 6990-06-3
• M. F.: C31H48O6
• M. W.: 516.70922

SYNONYMS

• IUPAC name: 2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-ylidene]-6-methylhept-5-enoic acid
• IUPAC Traditional name: ramycin
• Brand Name: Fusidine; Fucidin acid; Fucidin; Fucithalmic; Fucidin Cream 2%; Ramycin; Fucidine
• Synonyms: Fucidic acid; Diethanolamine fusidate; Fusidate; Fusidate Sodium; Fucidate Sodium; Fucidate

DATABASE IDS

• CAS Number: 6990-06-3
• PubChem CID: 3000226
• PubChem SID: 46505364

DETAILS

Description (English)

• Drug Groups: approved
• Description: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.
• Indication: For the treatment of bacterial infections.
• Pharmacology: Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.
• Affected Organisms: Enteric bacteria and other eubacteria
• Biotransformation: Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.
• Absorption: Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
• Half Life: Approximately 5 to 6 hours in adults.
• Protein Binding: 97 to 99%
• External Links: Wikipedia