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Cetirizine

Catalog No. DB00341 Name DrugBank
CAS Number 83881-51-0 Website http://www.ualberta.ca/
M. F. C21H25ClN2O3 Telephone (780) 492-3111
M. W. 388.8878 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 225

SYNONYMS

IUPAC name
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
IUPAC Traditional name
cetirizine
Brand Name
Reactine
Ziptek
Hitrizin Film Tablet
Zirtek
Zyrlex
Alerlisin
Cetryn
Formistin
Setir
Virlix
Zyrtec
Zyrtec Syrup
Zyrtec-D
Synonyms
Cetirizinum [Latin]
Cetirizina [Spanish]
Cetrizine Hcl

DATABASE IDS

PubChem SID 46508368
CAS Number 83881-51-0
PubChem CID 2678

PROPERTIES

Hydrophobicity(logP) 2.8
Solubility 101 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. [PubChem]
Indication For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria
Pharmacology Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis.
Toxicity Somnolence (sleepiness or unusual drowsiness), restlessness, irritability
Affected Organisms
Humans and other mammals
Absorption mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine
Half Life 8.3 hours
Protein Binding Very high (93%) plasma protein binding
Clearance * 53 mL/min [healthy]
External Links
Wikipedia
RxList
Drugs.com

REFERENCES