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Metixene

Catalog No. DB00340 Name DrugBank
CAS Number 4969-02-2 Website http://www.ualberta.ca/
M. F. C20H23NS Telephone (780) 492-3111
M. W. 309.46832 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 224

SYNONYMS

IUPAC name
1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
IUPAC Traditional name
metixene
Brand Name
Tremaril hydrochloride
Methixart
Atosil
Contalyl
Tremaril
Tremonil
Trest
Synonyms
Metixeno [INN-Spanish]
Methixene hydrochloride
Metixenum [INN-Latin]
Methixen [German]
Methixene
Metisene [DCIT]
Metixene hydrochloride

DATABASE IDS

PubChem SID 46508970
PubChem CID 4167
CAS Number 4969-02-2

PROPERTIES

Hydrophobicity(logP) 4.7
Solubility Soluble as HCl salt

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Metixene (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia]
Indication Used for the symptomatic treatment of parkinsonism.
Pharmacology Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Toxicity Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. Metabolism occurs via sulfoxydation and N-demethylation.
Absorption Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
References
[Link]
External Links
Wikipedia

REFERENCES