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Atenolol

Catalog No. DB00335 Name DrugBank
CAS Number 29122-68-7 Website http://www.ualberta.ca/
M. F. C14H22N2O3 Telephone (780) 492-3111
M. W. 266.33608 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 219

SYNONYMS

IUPAC name
2-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
IUPAC Traditional name
atenolol
Brand Name
Alinor
Atenol Von CT
Atenol Heumann
Noten
Tensimin
Atenol CT
Ateni
Atenol Atid
Atenol Trom
Atenol-Ratiopharm
Atereal
Cardaxen
Hipres
Normiten
Scheinpharm Atenol
Unibloc
Vericordin
Xaten
Altol
Atcardil
Atecard
Atenet
Atenol
Atenol 1A Pharma
Atenol Cophar
Atenol Fecofar
Atenol Gador
Atenol NM Pharma
Atenol Quesada
Atenol Tika
Corotenol
Farnormin
Felo-Bits
Loten
Lotenal
Plenacor
Prenormine
Teno-Basan
Tenobloc
Tenoblock
Tredol
Aircrit
Anselol
Atehexal
Atenblock
Atendol
Atenil
Atenol Acis
Atenol AL
Atenol Genericon
Atenol MSD
Atenol Nordic
Atenol PB
Atenol-Wolff
Atenolin
Atenomel
Aterol
Betablok
Betasyn
Betatop GE
Blocotenol
Blokium
Cardiopress
Cuxanorm
Duraatenolol
Hypoten
Jenatenol
Juvental
Lo-Ten
Myocord
Normalol
Oraday
Ormidol
Panapres
Premorine
Prenolol
Prinorm
Seles Beta
Serten
Servitenol
Stermin
Tenolol
Tenoprin
Tenormine
Uniloc
Vascoten
Wesipin
Antipressan
Apo-Atenolol
Atenol GNR
Atenol Stada
Atenol-Mepha
Betacard
Duratenol
Evitocor
Ibinolo
Internolol
Selobloc
Tenidon
Tenormin

DATABASE IDS

PubChem CID 2249
PubChem SID 46506915
CAS Number 29122-68-7

PROPERTIES

Hydrophobicity(logP) 0.5
Solubility 13.5 mg/mL

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect. [PubChem]
Indication For the management of hypertention and long-term management of patients with angina pectoris
Pharmacology Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the management of hypertension and edema.
Toxicity LD50=2000-3000 mg/kg(orally in mice). Symptoms of an atenolol overdose include a slow heart beat, shortness of breath, fainting, dizziness, weakness, confusion, nausea, and vomiting.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic (minimal)
Absorption Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces.
Half Life 6-7 hours
Protein Binding Plasma protein binding is 6-16%
Elimination Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces. Unlike propranolol or metoprolol, but like nadolol, atenolol undergoes little or no metabolism by the liver, and the absorbed portion is eliminated primarily by renal excretion.
External Links
Wikipedia
RxList
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REFERENCES