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Ethoxzolamide

Catalog No. DB00311 Name DrugBank
CAS Number 452-35-7 Website http://www.ualberta.ca/
M. F. C9H10N2O3S2 Telephone (780) 492-3111
M. W. 258.3173 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 196

SYNONYMS

IUPAC name
6-ethoxy-1,3-benzothiazole-2-sulfonamide
IUPAC Traditional name
ethoxzolamide
Brand Name
Diuretic C
Ethamide
Cardrase
Glaucotensil
Redupresin
Synonyms
Ethoxazolamide
Etoxzolamide
Ethoxyzolamide

DATABASE IDS

PubChem CID 3295
PubChem SID 46509023
CAS Number 452-35-7

PROPERTIES

Hydrophobicity(logP) 0.4
Solubility 40 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia. [PubChem]
Indication For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.
Pharmacology Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.
Affected Organisms
Humans and other mammals
Absorption Rapidly absorbed with 65% bioavailability
Half Life 2.5-5.5 hours
Protein Binding ~89%
External Links
Wikipedia

REFERENCES