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Flucloxacillin

Catalog No. DB00301 Name DrugBank
CAS Number 5250-39-5 Website http://www.ualberta.ca/
M. F. C19H17ClFN3O5S Telephone (780) 492-3111
M. W. 453.8717832 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 186

SYNONYMS

IUPAC name
(2S,5R,6R)-6-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
IUPAC Traditional name
(2S,5R,6R)-6-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Brand Name
Floxapen
Fluclox
Sesamol
Synonyms
Floxacillin
Flucloxacillinum [INN-Latin]
Flucloxacilline [INN-French]
Flucloxacilina [INN-Spanish]
Flucloxacillin Sodium
Flucloxacillin-Sodium

DATABASE IDS

PubChem CID 21319
CAS Number 5250-39-5
PubChem SID 46508276

PROPERTIES

Hydrophobicity(logP) 3.2

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Antibiotic analog of cloxacillin. [PubChem]
Indication Used to treat bacterial infection by susceptible microorganisms.
Pharmacology Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation Hepatic.
Absorption Bioavailability is 50–70% following oral administration.
Half Life 0.75–1 hour
External Links
Wikipedia

REFERENCES