Methotrexate hydrate

• Catalog No.: M8407
• CAS Number: 133073-73-1
• M. F.: C20H24N8O6
• M. W.: 472.45456
• Purity: ≥98% (HPLC)

SYNONYMS

• Title: 甲氨蝶呤 水合物
• IUPAC name: (2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
• IUPAC Traditional name: hydrate methotrexate
• Synonyms: 氨甲叶酸 水合物; MTX 水合物; L-氨甲喋呤 水合物; 对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物; 氟安定 水合物; 氨甲喋呤 水合物

DATABASE IDS

• PubChem SID: 24897252
• MDL Number: MFCD00150847
• CAS Number: 133073-73-1

PROPERTIES

• Purity: ≥98% (HPLC)
• Suitability: suitable for cell culture
• Suitability: suitable for insect cell culture
• Apperance: powder
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P301 + P310-P305 + P351 + P338-P308 + P313
• RID/ADR: UN 1544 6.1/PG 3
• Risk Statements: 61-25-36/38
• Safety Statements: 53-26-36/37-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Frequently Asked Questions
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Application
Recommended for use in cell culture and molecular biology applications at 0.01-300 μM in nucleoside-free cell culture medium to select for DHFR expression.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Biochem/physiol Actions
Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.