Acetazolamide

• Catalog No.: A6011
• CAS Number: 59-66-5
• M. F.: C4H6N4O3S2
• M. W.: 222.24544
• Purity: ≥99%

SYNONYMS

• IUPAC name: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
• IUPAC Traditional name: acetazolamide
• Synonyms: N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide; 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide; N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

DATABASE IDS

• PubChem SID: 24278144
• CAS Number: 59-66-5
• EC Number: 200-440-5
• MDL Number: MFCD00003105

PROPERTIES

• Purity: ≥99%
• Gene Information: human ... CA1(759), CA12(771), CA14(23632), CA2(760), CA3(761), CA5A(763), CA5B(11238), CA9(768)mouse ... Car13(71934), Car5a(12352)rat ... Car2(54231), Car4(29242)
• pKa: 7.2
• Apperance: powder
• Solubility: 1 M NH4OH: soluble50 mg/mL
• Solubility: DMSO: soluble
• Solubility: methanol and ethanol: slightly soluble
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 36/38
• RTECS: AC8225000
• Safety Statements: 26
• German water hazard class: 2

DETAILS

Description (English)

Application
Carbonic anhydrase inhibitor; increases cerebral blood flow.
Biochem/physiol Actions
Inhibits water permeability of membranes by interacting with aquaporins1,2
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A6011.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.