Plumbagin from Plumbago indica

• Catalog No.: P7262
• CAS Number: 481-42-5
• M. F.: C11H8O3
• M. W.: 188.17942

SYNONYMS

• IUPAC name: 5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione
• IUPAC Traditional name: plumbagin
• Synonyms: 5-Hydroxy-2-methyl-1,4-naphthoquinone

DATABASE IDS

• MDL Number: MFCD00001682
• PubChem SID: 24898833
• EC Number: 207-569-6
• CAS Number: 481-42-5

PROPERTIES

• Melting Point: 76-78 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H314
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P280-P305 + P351 + P338-P310
• RID/ADR: UN 2923 8/PG 2
• Risk Statements: 25-34
• RTECS: QL8500000
• Safety Statements: 22-26-36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 8
• UN Number: 2923
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action.
Plumbagin exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma. Plumbagin is a unique suppressor of CXCR4 expression making in useful in studies of cancer metastasis. Plumbagin has antifungal, antiviral, and antibacterial action.