Filipin III from Streptomyces filipinensis

• Catalog No.: F4767
• CAS Number: 480-49-9
• M. F.: C35H58O11
• M. W.: 654.82842
• Purity: ≥85% (HPLC)

SYNONYMS

• IUPAC name: (17Z,19Z,21Z,23Z,25Z)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
• IUPAC Traditional name: (17Z,19Z,21Z,23Z,25Z)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

DATABASE IDS

• PubChem SID: 24894871
• CAS Number: 480-49-9
• MDL Number: MFCD00466923

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: RN9800000
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3
• Purity: ≥85% (HPLC)
• Quality Level: PREMIUM

DETAILS

Description (English)

Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols.4 Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.5
Other Notes
Filipin III is the major component of 8 isomeric components in filipin.
Application
Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel1 and immobilized on nitrocellulose membranes.2 It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.3