α-Estradiol

• Catalog No.: E8750
• CAS Number: 57-91-0
• M. F.: C18H24O2
• M. W.: 272.38196
• Purity: ≥98% (TLC)

SYNONYMS

• Title: α-雌二醇
• IUPAC name: (1S,10R,11S,14R,15S)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,14-diol
• IUPAC Traditional name: estradiol 17 α
• Synonyms: 雌二醇; 1,3,5(10)-雌甾三烯-3,17α-二醇; 3,17α-二羟基-1,3,5(10)-雌三烯

DATABASE IDS

• MDL Number: MFCD00064144
• PubChem SID: 24894682
• CAS Number: 57-91-0
• EC Number: 200-354-8

PROPERTIES

• Purity: ≥98% (TLC)
• Gene Information: human ... ESR1(2099), ESR2(2100)rat ... Ar(24208)
• Apperance: white with slight yellow cast powder
• Solubility: ethanol: soluble50 mg/mL, clear, colorless
• GHS Signal Word: Warning
• GHS Hazard statements: H351
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P281
• Risk Statements: 40-48
• RTECS: KG3750000
• Safety Statements: 22-24/25
• German water hazard class: 3

DETAILS

Description (简体中文)

Frequently Asked Questions
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Biochem/physiol Actions
雌二醇（称为 α-雌甾二醇或 17α-雌二醇）为人类乳腺癌细胞组织培养中的生物活性雌激素。17-雌二醇及其选择性受体 (ER-X) 不是传统激素/受体内分泌系统的一部分，而是在成人大脑生长中具有重要自分泌/旁分泌功能的系统的一部分。在更年期以及神经退化性疾病（例如阿尔茨海默氏病和缺血性中风）的治疗中，17-雌二醇可能对激素替代物疗法具有重要意义。