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α-Estradiol

Catalog No. E8750 Name Sigma Aldrich
CAS Number 57-91-0 Website http://www.sigmaaldrich.com
M. F. C18H24O2 Telephone 1-800-521-8956
M. W. 272.38196 Fax
Purity ≥98% (TLC) Email
Storage Chembase ID: 134351

SYNONYMS

Title
α-雌二醇
IUPAC name
(1S,10R,11S,14R,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-triene-5,14-diol
IUPAC Traditional name
estradiol 17 α
Synonyms
雌二醇
1,3,5(10)-雌甾三烯-3,17α-二醇
3,17α-二羟基-1,3,5(10)-雌三烯

DATABASE IDS

MDL Number MFCD00064144
PubChem SID 24894682
CAS Number 57-91-0
EC Number 200-354-8

PROPERTIES

Purity ≥98% (TLC)
Gene Information human ... ESR1(2099), ESR2(2100)rat ... Ar(24208)
Apperance white with slight yellow cast powder
Solubility ethanol: soluble50 mg/mL, clear, colorless
GHS Pictograms GHS08
GHS Signal Word Warning
GHS Hazard statements H351
European Hazard Symbols Harmful Harmful (Xn)
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P281
Risk Statements 40-48
RTECS KG3750000
Safety Statements 22-24/25
German water hazard class 3

DETAILS

Description (简体中文)
Frequently Asked Questions
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Biochem/physiol Actions
雌二醇(称为 α-雌甾二醇或 17α-雌二醇)为人类乳腺癌细胞组织培养中的生物活性雌激素。17-雌二醇及其选择性受体 (ER-X) 不是传统激素/受体内分泌系统的一部分,而是在成人大脑生长中具有重要自分泌/旁分泌功能的系统的一部分。在更年期以及神经退化性疾病(例如阿尔茨海默氏病和缺血性中风)的治疗中,17-雌二醇可能对激素替代物疗法具有重要意义。

REFERENCES