Pipemidic acid

• Catalog No.: P7903
• CAS Number: 51940-44-4
• M. F.: C14H17N5O3
• M. W.: 303.31648

SYNONYMS

• IUPAC name: 8-ethyl-5-oxo-2-(piperazin-1-yl)-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxylic acid
• IUPAC Traditional name: pipemidic acid
• Synonyms: 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid

DATABASE IDS

• PubChem SID: 24898889
• CAS Number: 51940-44-4
• MDL Number: MFCD00057291
• EC Number: 257-530-2

PROPERTIES

• German water hazard class: 2
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• Safety Statements: 22-36/37-45
• Gene Information: human ... CYP1A2(1544)

DETAILS

Description (English)

Application
Pipemidic acid is used to study DNA damage and mutagenic activity1. It has been used to induce articular lesions in the neonatal mouse2 and is used to study human lymphocyte blastogenesis and γ-interferon production 3.
Biochem/physiol Actions
Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis3.
Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P7903.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.