Mizoribine

• Catalog No.: M3047
• CAS Number: 50924-49-7
• M. F.: C9H13N3O6
• M. W.: 259.21602
• Purity: ≥98% (TLC)

SYNONYMS

• IUPAC name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide
• IUPAC Traditional name: bredinin
• Synonyms: N′-(β-D-Ribofuranosyl)-5-hydroxy-imida-zole-4-carboxamide

DATABASE IDS

• MDL Number: MFCD00057221
• CAS Number: 50924-49-7
• PubChem SID: 24278546

PROPERTIES

• Purity: ≥98% (TLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H319-H335-H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P261-P305 + P351 + P338-P308 + P313
• Risk Statements: 46-60-61-36/37/38
• RTECS: NI3980000
• Safety Statements: 53-22-26-36/37/39-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Mizoribine is an imidazole nucleoside possessing strong immunosuppressive properties. Selectively blocks T-cell proliferation response to mitogenic and allo-antigenic stimulation. Mizoribine blocks the movement of T cells from G to S phase. In addition, it significantly decreases the number of B cells at the S, G, and M phases. Mizoribine inhibits de novo synthesis of nucleotides by inhibition of inosine monophosphate dehydrogenase. The resulting nucleotide depletion inhibits DNA synthesis.