Amiloride hydrochloride hydrate

• Catalog No.: A7410
• CAS Number: 2016-88-8(anhydrous)
• M. F.: C6H11Cl2N7O2
• M. W.: 284.10324
• Purity: ≥98% (TLC)

SYNONYMS

• IUPAC name: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrate hydrochloride
• IUPAC Traditional name: amilorida hydrate hydrochloride
• Synonyms: N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

DATABASE IDS

• MDL Number: MFCD03703482
• PubChem SID: 24277817
• CAS Number: 2016-88-8(anhydrous)

PROPERTIES

• Purity: ≥98% (TLC)
• Gene Information: human ... ABP1(26), ACCN1(40), ACCN2(41), PLAU(5328), SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), TNF(7124)mouse ... Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544)rat ... Abp1(65029), Accn1(25364), Accn2(79123), Plau(25619), Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782)
• Apperance: yellow powder
• Solubility: H2O: soluble50 mg/mL, clear, yellow-green
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• Safety Statements: 45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Caution
Protect from light.
Application
Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.
Biochem/physiol Actions
Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).