2-Methoxyestradiol

• Catalog No.: M6383
• CAS Number: 362-07-2
• M. F.: C19H26O3
• M. W.: 302.40794

SYNONYMS

• IUPAC name: (1S,10R,11S,14S,15S)-4-methoxy-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,14-diol
• IUPAC Traditional name: 2-methoxyestradiol
• Synonyms: 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether; 2-Hydroxyestradiol 2-methyl ether; 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene; 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether

DATABASE IDS

• CAS Number: 362-07-2
• PubChem SID: 24278561
• MDL Number: MFCD00010489

PROPERTIES

• Gene Information: human ... ESR1(2099), ESR2(2100)
• Apperance: white to faint yellow powder
• Solubility: DMSO: soluble10 mg/mL
• Solubility: ethanol: soluble10 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H311-H315-H319-H331-H335-H350-H360-H372
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P261-P280-P301 + P310-P305 + P351 + P338-P311
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 45-46-60-61-23/24/25-36/37/38-48
• RTECS: KG7537500
• Safety Statements: 53-22-26-36/37/39-45
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis. A major estradiol metabolite, it has little affinity for classical estrogen receptors.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6383.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.