N-Acetylprocainamide hydrochloride

• Catalog No.: A5513
• CAS Number: 34118-92-8
• M. F.: C15H24ClN3O2
• M. W.: 313.82296
• Purity: ≥99% (HPLC)

SYNONYMS

• Title: N-乙酰普鲁卡因胺 盐酸盐
• IUPAC name: N-[2-(diethylamino)ethyl]-4-acetamidobenzamide hydrochloride
• IUPAC Traditional name: NAPA hydrochloride
• Synonyms: N-乙酰普卡胺 盐酸盐; 乙酰卡尼 盐酸盐; NAPA

DATABASE IDS

• CAS Number: 34118-92-8
• MDL Number: MFCD00012501
• EC Number: 251-831-2
• PubChem SID: 24890983

PROPERTIES

• Purity: ≥99% (HPLC)
• Apperance: powder
• Melting Point: 184-186 °C(lit.)
• Solubility: H2O: soluble50 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Application
N-Acetylprocainamide hydrochloride is a class III antiarrhythmic compound. N-Acetylprocainamide hydrochloride has been used in a study to determine the disposition of procainamide and N-acetylprocainamide in protein-calorie malnutrition. N-Acetylprocainamide hydrochloride has also been used to study pharmacokinetics of procainamide and N-acetylprocainamide in rats.
Biochem/physiol Actions
III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。