Flumethasone

• Catalog No.: F9507
• CAS Number: 2135-17-3
• M. F.: C22H28F2O5
• M. W.: 410.4515264

SYNONYMS

• IUPAC name: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-5-one
• IUPAC Traditional name: flumethasone
• Synonyms: 6α,9α-Difluoro-16α-methylprednisolone; 6α-Fluorodexamethasone; 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione

DATABASE IDS

• CAS Number: 2135-17-3
• MDL Number: MFCD00056464
• PubChem SID: 24894998
• EC Number: 218-370-9

PROPERTIES

• German water hazard class: 3
• GHS Signal Word: Warning
• GHS Hazard statements: H351
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P281
• Risk Statements: 40
• RTECS: TU3832000
• Safety Statements: 22-36
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Application
Flumethasone pivalate is a topical corticosteroid. Prompt decrease in inflammation, exudation and itching is experienced after application. It is a difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. Flumethasone is a corticosteroid commonly used in veterinary practice1 and has been used in cortisol assays to study early porcine conceptus development2.
Biochem/physiol Actions
Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding.
Flumethasone is a glucocorticoid receptor agonist. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding .