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Sulfanitran

Catalog No. S5272 Name Sigma Aldrich
CAS Number 122-16-7 Website http://www.sigmaaldrich.com
M. F. C14H13N3O5S Telephone 1-800-521-8956
M. W. 335.33512 Fax
Purity ~85% Email
Storage Chembase ID: 104658

SYNONYMS

Title
磺胺硝苯
IUPAC name
N-{4-[(4-nitrophenyl)sulfamoyl]phenyl}acetamide
IUPAC Traditional name
sulfanitran
Synonyms
N4-乙酰基-N1-(4-硝基苯)磺胺

DATABASE IDS

PubChem SID 24899645
CAS Number 122-16-7
MDL Number MFCD00024598
Beilstein Number 2952955

PROPERTIES

Purity ~85%
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class 3

DETAILS

Description (English)
Application
Sulfanitran is used to stimulate MRP2. It is used to stimulate the MRP2-mediated transport of lipophilic amphipathic drugs1. It is used to study the efflux of chemotherapeutics in tumor cell lines1.
Biochem/physiol Actions
Sulfanitran stimulates the ATP binding cassette family transporter multidrug resistance protein 2 (MRP2). Sulfanitran increases the affinity of MRP2 for estradiol-17-β-D-glucuronide2. It stimulates the vectorial transport of saquinavir, a MRP2 substrate, across polarized MDCKII monolayers2.

REFERENCES