Sulfadiazine

• Catalog No.: S8626
• CAS Number: 68-35-9
• M. F.: C10H10N4O2S
• M. W.: 250.277
• Purity: ≥99.0%

SYNONYMS

• Title: 磺胺嘧啶
• IUPAC name: 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
• IUPAC Traditional name: sulfadiazine
• Synonyms: N-2-嘧啶基-4-氨基苯磺酰胺; N1-(嘧啶-2-基)磺胺

DATABASE IDS

• PubChem SID: 24899802
• CAS Number: 68-35-9
• MDL Number: MFCD00006065
• Beilstein Number: 6733588
• EC Number: 200-685-8

PROPERTIES

• Purity: ≥99.0%
• Suitability: suitable for 1694 per US EPA
• Melting Point: 253 °C (dec.)(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 22-36/37/38-42/43
• RTECS: WP1925000
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (简体中文)

包装
25, 50, 100, 250, 500 g in poly bottle
Application
Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections1. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis2.
Biochem/physiol Actions
Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.