Nigericin sodium salt

• Catalog No.: N7143
• CAS Number: 28643-80-3
• M. F.: C40H67NaO11
• M. W.: 746.94315
• Purity: ≥98% (TLC)

SYNONYMS

• IUPAC name: sodium (2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl}-3-methyloxan-2-yl]propanoate
• IUPAC Traditional name: sodium (2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl}-3-methyloxan-2-yl]propanoate
• Synonyms: Helexin C; Antibiotic X464; Azalomycin M; Antibiotic K178; Polyetherin A

DATABASE IDS

• CAS Number: 28643-80-3
• Beilstein Number: 3892398
• MDL Number: MFCD00036825
• PubChem SID: 24897813

PROPERTIES

• Biological Source: from Streptomyces hygroscopicus
• Purity: ≥98% (TLC)
• Quality Level: PREMIUM
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 3462 6.1/PG 3
• Risk Statements: 25-36/37/38
• RTECS: QT6840000
• Safety Statements: 26-36/37/39-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria.
Polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.
Other Notes
As ion-selective electrode - an efficient K+-carrier.1,2