5′-Deoxy-5′-(methylthio)adenosine

• Catalog No.: D5011
• CAS Number: 2457-80-9
• M. F.: C11H15N5O3S
• M. W.: 297.3335

SYNONYMS

• IUPAC name: (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol
• IUPAC Traditional name: methylthioadenosine
• Synonyms: Methylthioadenosine; MTA

DATABASE IDS

• MDL Number: MFCD00010533
• CAS Number: 2457-80-9
• Beilstein Number: 42420
• PubChem SID: 24893915

PROPERTIES

• Gene Information: human ... ADORA2B(136), ADORA3(140)mouse ... Mtap(66902)rat ... Adora1(29290), Adora2a(25369)
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: AU7410000
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D5011.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.