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Thiamphenicol

Catalog No. T0261 Name Sigma Aldrich
CAS Number 15318-45-3 Website http://www.sigmaaldrich.com
M. F. C12H15Cl2NO5S Telephone 1-800-521-8956
M. W. 356.2222 Fax
Purity Email
Storage Chembase ID: 6228

SYNONYMS

IUPAC name
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
IUPAC Traditional name
thiamphenicol
Synonyms
D-threo-2,2-Dichloro-N-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide

DATABASE IDS

CAS Number 15318-45-3
MDL Number MFCD00467983
PubChem SID 24899874
Beilstein Number 2819542
EC Number 239-355-3

PROPERTIES

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS AB6680000
German water hazard class 2

DETAILS

Description (English)
Application
Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea1,2. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered3.
Biochem/physiol Actions
Thiamphenicol inhibits mitochondrial protein synthesis of proteins such as cytochrome c oxidase.

REFERENCES