Ascomycin from Streptomyces hygroscopicus var. ascomyceticus

• Catalog No.: A3835
• CAS Number: 104987-12-4
• M. F.: C43H69NO12
• M. W.: 792.00746

SYNONYMS

• IUPAC name: (1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC Traditional name: ascomycin

DATABASE IDS

• CAS Number: 104987-12-4
• MDL Number: MFCD06198665
• PubChem SID: 24890817

PROPERTIES

• Safety Statements: 36/37
• Storage Temperature: -20°C
• German water hazard class: 3
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• RTECS: KD4185000

DETAILS

Description (English)

Linkage
An FK506 analog with an ethyl rather than an allyl group at position 21.
Biochem/physiol Actions
Strong immunosuppressant; inhibits allogenic T-lymphocyte proliferation. It binds with high affinity to FKBP and inhibits calcineurin phosphatase in the nM range.