Okadaic acid from Prorocentrum concavum

• Catalog No.: O9381
• CAS Number: 78111-17-8
• M. F.: C44H68O13
• M. W.: 805.00292
• Purity: 92-100% (HPLC)

SYNONYMS

• IUPAC name: (2R)-3-[(2S,5R,6R,8S)-8-[(2R,3E)-4-[(2R,4'aR,5R,6'S,8'R,8'aS)-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-7'-methylidene-hexahydro-3'H-spiro[oxolane-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl]-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid
• IUPAC Traditional name: okadaic acid
• Synonyms: OA

DATABASE IDS

• CAS Number: 78111-17-8
• PubChem SID: 24898069
• MDL Number: MFCD00083455

PROPERTIES

• Purity: 92-100% (HPLC)
• Shipped in: dry ice
• Solubility: DMSO: ≥1 mg/mL
• Solubility: ethanol: ≥1 mg/mL
• Solubility: methanol: ≥1 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H311-H315-H331
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P280-P301 + P310-P311
• RID/ADR: UN 3462 6.1/PG 1
• Risk Statements: 23/24/25-38
• RTECS: AA8227800
• Safety Statements: 26-36/37-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

Preparation Note
Isolated from unialgal cultures of dinoflagellates.
Biochem/physiol Actions
Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.