Home > Compound List > Product Information
Staurosporine from Streptomyces sp._Molecular_structure_CAS_62996-74-1)
Click picture or here to close

Staurosporine from Streptomyces sp.

Catalog No. S5921 Name Sigma Aldrich
CAS Number 62996-74-1 Website http://www.sigmaaldrich.com
M. F. C28H26N4O3 Telephone 1-800-521-8956
M. W. 466.53104 Fax
Purity ≥95% (HPLC) Email
Storage Chembase ID: 134161

SYNONYMS

IUPAC name
(2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one
IUPAC Traditional name
(2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one
Synonyms
Antibiotic AM-2282

DATABASE IDS

CAS Number 62996-74-1
PubChem SID 24899680
Beilstein Number 1060573
MDL Number MFCD00077402

PROPERTIES

Grade for molecular biology
Purity ≥95% (HPLC)
Quality Level PREMIUM
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H340-H350
European Hazard Symbols Toxic Toxic (T)
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P308 + P313
Risk Statements 45-46
Safety Statements 53-45
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Analysis Note
Tested for inhibition of interleukin 2 production in Jurkat cells.
Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.

REFERENCES