Staurosporine from Streptomyces sp.

• Catalog No.: S4400
• CAS Number: 62996-74-1
• M. F.: C28H26N4O3
• M. W.: 466.53104
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one
• IUPAC Traditional name: (2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one
• Synonyms: Antibiotic AM-2282

DATABASE IDS

• CAS Number: 62996-74-1
• PubChem SID: 24899603
• Beilstein Number: 1060573
• MDL Number: MFCD00077402

PROPERTIES

• Purity: ≥95% (HPLC)
• Quality Level: PREMIUM
• Apperance: film
• Solubility: DMSO: soluble
• Solubility: H2O: insoluble
• Solubility: ethanol: soluble
• Solubility: methanol: soluble
• GHS Signal Word: Danger
• GHS Hazard statements: H340-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45-46
• Safety Statements: 53-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.