Hydrocortisone

• Catalog No.: H0135
• CAS Number: 50-23-7
• M. F.: C21H30O5
• M. W.: 362.4599

SYNONYMS

• Title: 氢化可的松
• IUPAC name: (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• IUPAC Traditional name: hydrocortisone
• Synonyms: 11β,17α,21-三羟基孕甾-4-烯-3,20-二酮; 皮质醇; 氢化泼尼松龙; 氢化皮质酮; 17-羟基皮质甾酮; 4-孕烯-11β,17α,21-三醇-3,20-二酮

DATABASE IDS

• MDL Number: MFCD00011654
• Beilstein Number: 1354819
• PubChem SID: 24895394
• CAS Number: 50-23-7
• EC Number: 200-020-1

PROPERTIES

• Potency: 0.004-5 μg/mL
• Sterility: γ-irradiated
• Suitability: suitable for cell culture
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), SERPINA6(866)mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)rat ... Ar(24208), Nr3c1(24413)
• Apperance: powder
• Melting Point: 211-214 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H361
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P281
• Risk Statements: 63
• RTECS: GM8925000
• Safety Statements: 36/37
• German water hazard class: 3

DETAILS

Description (简体中文)

General description
用于上皮和内皮贴壁细胞培养的氢化可的松。
Reconstitution
要制备 50μg/mL 的储存液，可加入 1mL 无水乙醇，温和搅拌使之溶解，在搅拌下加入 19mL 无菌培养基。
Physical form
室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻
Biochem/physiol Actions
肾上腺皮质分泌的原发性糖皮质激素。消炎效果是皮质酮的三倍，但 Na2+ 保留性能比皮质酮低。