Nocodazole

• Catalog No.: M1404
• CAS Number: 31430-18-9
• M. F.: C14H11N3O3S
• M. W.: 301.32044
• Purity: ≥99% (TLC)

SYNONYMS

• IUPAC name: methyl N-[5-(thiophene-2-carbonyl)-1H-1,3-benzodiazol-2-yl]carbamate
• IUPAC Traditional name: nocodazol
• Synonyms: R 17934; Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate; [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester; Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate; Oncodazole

DATABASE IDS

• CAS Number: 31430-18-9
• MDL Number: MFCD00005588
• PubChem SID: 24278535
• Beilstein Number: 1085978
• EC Number: 250-626-5

PROPERTIES

• Purity: ≥99% (TLC)
• Quality Level: PREMIUM
• Gene Information: human ... TUBB(203068)
• Apperance: white powder
• Melting Point: 300 °C (dec.)
• Solubility: DMSO: soluble10 mg/mL (may require heating)
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H341-H361d
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS Precautionary statements: P281
• Risk Statements: 63-68
• RTECS: DD6521000
• Safety Statements: 36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to β?tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Arrests the cell cycle at G2/M phase. Prevents phosphorylation of the T cell antigen receptor and inhibits its activity. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway and induces apoptosis in several normal and tumor cell lines.