S-(5′-Adenosyl)-L-methionine chloride dihydrochloride

• Catalog No.: A7007
• CAS Number: 86867-01-8
• M. F.: C15H23ClN6O5S
• M. W.: 434.89832
• Purity: ≥80%

SYNONYMS

• IUPAC name: [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium chloride
• IUPAC Traditional name: SAMe chloride
• Synonyms: AdoMet; SAM chloride dihydrochloride; Active methionine

DATABASE IDS

• PubChem SID: 24891164
• CAS Number: 86867-01-8
• EC Number: 246-184-8
• Beilstein Number: 6560002
• MDL Number: MFCD22571809

PROPERTIES

• Biological Source: from yeast (L-Methionine enriched)
• Purity: ≥80%
• Shipped in: dry ice
• Solubility: H2O: soluble100 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Analysis Note
Purity based on UV and HPLC.
Caution
This material is 80-90% pure when prepared, but is very unstable. As much as 10% purity loss per day at 25 °C has been noted.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.