Orotic acid

• Catalog No.: O2750
• CAS Number: 65-86-1
• M. F.: C5H4N2O4
• M. W.: 156.09626
• Purity: ≥98% (titration)

SYNONYMS

• Title: 乳清酸
• IUPAC name: 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
• IUPAC Traditional name: orotic acid
• Synonyms: 6-Carboxy-2,4-dihydroxypyrimidine; 6-Carboxyuracil; 2,6-Dihydroxypyrimidine-4-carboxylic acid; Uracil-6-carboxylic acid

DATABASE IDS

• CAS Number: 65-86-1
• EC Number: 200-619-8
• MDL Number: MFCD00006027
• PubChem SID: 24897967
• Beilstein Number: 383901

PROPERTIES

• Grade: anhydrous
• Purity: ≥98% (titration)
• Melting Point: ≥300 °C
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• RTECS: RM3180000
• Safety Statements: 26
• German water hazard class: 3

DETAILS

Description (English)

Application
Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.