α-Amanitin

• Catalog No.: A2263
• CAS Number: 23109-05-9
• M. F.: C39H54N10O14S
• M. W.: 918.96966
• Purity: ≥90% (HPLC)

SYNONYMS

• IUPAC name: 2-[34-(butan-2-yl)-13-(3,4-dihydroxybutan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27λ^4-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0^6,^1^0.0^1^8,^2^6.0^1^9,^2^4]nonatriaconta-18(26),19,21,23-tetraen-4-yl]acetamide
• IUPAC Traditional name: α-amanitin

DATABASE IDS

• CAS Number: 23109-05-9
• Beilstein Number: 1071138
• PubChem SID: 24890639
• EC Number: 245-432-2
• MDL Number: MFCD00215842

PROPERTIES

• Biological Source: from Amanita phalloides
• Purity: ≥90% (HPLC)
• Absorption Wavelength: ε1M/310 nm, H2O 13,500
• Apperance: white to light yellow powder
• Melting Point: 254-255 °C(lit.)
• Solubility: H2O: soluble1.0 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330-H373
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 3462 6.1/PG 2
• Risk Statements: 26/27/28-33
• RTECS: BD6195000
• Safety Statements: 36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 3462
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Asn-Hyp-Hyi-Trp-Gly-Ile-Gly-Cys [Bridge: 4-8]
Caution
When stored frozen in the dark, retained samples were found to be greater than 99% by HPLC after two years.
Reconstitution
Store a 1 mg/ml aqueous stock solution frozen at -20°C. It does not degrade with repeated freeze-thaw cycles. Dilute into the appropriate buffer immediately prior to use. Product is destroyed by concentrated acid or base.
Biochem/physiol Actions
The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.